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I am of African American decent and at age 47, my DNA resulted in over 10% European (Scottish/Irish). Now at age 49, Dupuytrens (aka Vikings Disease) reared its ugly head.

Thanks. There are so many others outside the group's you describe as those at risk. Something just speed up the weakening of the tendons, then something must mutate that cause the lumpies.

I would be interested in participating in some sort of research for you. My mom had to return contractor and I have pictures of the conditions of both of her hands she had surgery one time and it came back again. Now I have to return contracture and I am trying to do some counter stretching I have a contraption that I bought that I put on that pulls my fingers backwards to stretch and I'm hoping that that will counter the pulling that goes in the opposite direction. I prefer not to have injections and surgery so hopefully this will help I'm still able to put my whole Palm down on the table but I can definitely feel the pulling and I can see the nodules on my hand

I’m so so so so tired of the pain in both hands and both feet, that I’ve actually looked up bionic feet and hands…help!!!

That looks so painful and scary. Question: If you are dissecting the tendons in question, how is the patient able to make a fist and release after procedure? It seems not likely, to me.

I had a Football catch in my early 20s where the Football was thrown too hard at me & jammed my pinky or so I thought. Tremendous pain for days & once the pain sufficed I had a Pinky bent at both knuckle joints unable to move so now assumed I broke my pinky. Fast forward & I am now 46 diagnosed w/ Dupuytren cuz I went in for my Pinky I neglected but after years of manual labor I had Cords while I know all of the above are Injuries cuz a Football cannot carry Diseases.

I would like to know if this is considered an autoimmune issue.

Ok

Excellent and informative video! Thank you! One note: That’s American painter Andrew Wyeth, not physicist Max Planck :)

Amazing! Thank you.

Interesting. I have chronic sarcoidosis. I am half Korean plus 25% black, plus 25% northern European (paternal grandfather was half black, half European). I believe I have a Dupuytren nodule. I noticed that sarcoidosis was on your chart.

Lemon ginger few drops good oil green tea help, I give my mom . No milk no sugar only natural sugar,

Cholesterol is a biomarker for commercial opportunity - not disease. There will be no medication for Dupuytren's until someone figures out how to monetise it.

I have the signature lumps on the palm and one being closer under the knuckle. I tend to stretch it before bedtime and after I wake up. I know in time i will probably have to see a medical professional in the future. However, the stretching of the fingers help me significantly.

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Radiation treatment? Xrays Since 1933. Started in Germany. Look into it.

No mention of radiation treatment?! Surgeons like to cut. It is what they know. If you need to keep the dexterity in your hands the sugery will not help. The enzymes are terribly expensive and have to be repeated. Also they can be risky as well. Look into radiation and you will see another option that may save your hand’s dexterity.

Thank you, very informative and well presented.

Can you preci cely tell the blood markers to look for,pls. One of the best video on this topic.

Have they set up a database? Who is collecting and collating the data?

@Dupuytren'sResearchGroup look at the use of computer mouse as a type of damage to the hand.

Magnificent

Find Jefferson. He will cure you with his magic terry cloth touch. He's a miracle worker.

What stops the collagenase from eating through cartilage?

I’m lucky I have trigger finger and thumb and Dupuytrens.

Thank you! . Does light stretching of the hand with the disease help delay or accelerate the symptoms ? I am In the early stages (pinky and ring finger) and want to stretch mine in hopes it slows down the curling of the fingers.

I do push ups every day. 20 years, Could this cause it? Pressure on my palms.

I've got this in both hands,I've had one operation on each hand and didn't work , now I'm in so much pain and I can't perform my job properly and I'm having trouble holding on to my job. If you have it as bad as me it's a disability, I can't wash my face as I can't cup water in my hands, if I wash my hair it gets tangled around my fingers. I can't open things I drop things , if I open a door and let go I'm still stuck to the handle and have to pull my fingers off the handle. It is horrible. People at work don't believe me and say oh just get on with it, this isn't the case and causes me lots of stress. You have to learn how to adapt to every day life the best way you can, take in mind it will take you twice as long so you also have to learn to be patience .

I am a climber and taking collagen suppliments to aid my climbing does this effect my dupuytren

Yes, painful tightness in my palms, fingers, wrists, forearms. Started in the middle of my palm and my fingers swelled up & became stiff. I think the fascia became inflamed and is pulling on the ligaments, tendons and muscles upstream and down. Anyone else?

Thank you for an excellent presentation on Dupuytrens Disease. I always embraced the Notion that it was of Viking/Neanderthal genotype introduced into the modern phenotype.

What is the role of adalimumab injections in the reversal of Dupuytrens Contracture following the Oxford Study? Will this treatment make surgery obsolete ?

Clumsiness in picking up Mahjong tiles and dropping them. Also when preparing food in the kitchen. Clipping a dog lead on or releasing. Movements when holding a cleaning cloth are painful. Pressing large door entry buttons is painful. Opening jars and bottles difficult. Vibration from holding the steering handles of a mobility scooter on bumpy paths may worsen the condition. Use a foam absorption layer and thick gloves.

Is there a connection with Hashimoto's thyroid failure? I have total failure and Depuytren in both hands and my feet are also affected, complicated by having diabetic neuropathy and carpal/ulnal tunnel.

I have been struggling with this disease since 1995 as a 21 year old. I believe trauma was my trigger, In 95 my right hand was affected and it was never apparent until I was ran over and slammed in-between two cars breaking my arm and impacting my hand. Two or three weeks later I immediately formed lumps in my hand and my fingers started to twist and pull in. I had went 15+ years before having the surgery. Fast forward to 2014 I got into a motorcycle accident that crushed my collar bone, shoulder blade, vertebrae extensive damage to left side and hand, a few weeks later I got those lumps in my left hand and started to distort my fingers and pull them in. Since to date I have had 5 surgeries on each hand. My last surgery was on 12/27/2023 on my right hand. I firmly believe DRs know squat about this disease.

My brother has had three surgeries, so I have been watching. I am 62 and had no symptoms until I took Cipro. I ended up with torn Achilles tendons and a year later a hard cyst in my hand and hard thick tendon and drawing slightly of pinky finger. I'm wondering if this is a reoccurring situation with floxins triggering this to happen in people's hands.?

I am 26 yrs old and not of Nothern European decent but I am fully Southern European (Half Serbian, Half Maltese) and I got diagnosed with dupuytrens around last October. I got this condition after I have punched a wall and fractured my hamate bone and the 4/5 finger knuckles. As a resulf of trauma I got the Dupuytrens condition. As I noticed the lumps on my hand I went to visit a physiotherapist who referred me to do an ultrasound to confirm the condition. Since its in the early stages I am currently taking care by grip strenghtening, finger/hand palm stretching, dipping my hand in hot water with dead sea salt, overnight castor oil pack and vitamin E oil. Also I am reducing alcohol and cigarettes intake as I was drinking lots and lots of alcohol (which honestly I think flared this condition) hopefully if I keep it under control by doing the mentioned treatment I will not get any severe contractures. A weird condition but I guess I m paying for my anger management issues too. Never will punch a wall again.

Any idea as to how far in advance Dupuytren's disease can cause clumsiness or issues with fine dexterity prior to the physical manifestation of nodules/chords? I started having difficulty with my middle and ring fingers when playing guitar, about five years before nodules appeared. Wondering if very early Dupuytren's was responsible for that or if it was something else.

I had surgery in my right hand back in 1999, its back. I have 2 knodgels in my left hand that just popped up. I have it in my left foot since I was in my late 20's and it causes my foot to cramp up. I have many health issues and have had them since I was 2, im now 67. I was just told that I need to have surgery on my hand. Well both hands. I have no family medical information that I can look into.

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I'm screwed. Had it since my early 20s, hasn't really progressed but sucks every day. My thumb is effected and painful that bothers me every day. My fingers are in a more moderate state. Yet they still are hard to open.

Please answer my questions re shockwave treatment ,let's just use our intelligence intuition shall we More money waisted ,I see ! All this says to me let me do endless research and pay me rather than find and use treatments sounds as iv you dont really care rather let's play eround in a lab ,there ard psychological names for this sorry but you are insulting people research ISNT as imp as treatment .

PLEASE 1:18 in even a decent graduate student can see this the only really significant thing said at this stage it is an adaptive ir overactive resp to damage common in mechanics in people who routinely use tools probably 90% more ar risk or once bones broken etc the bodies production of collegenaze compromised healing cycle partil ..Your missing the point You are missing alot context or circumstance ,ie my bike accident and surgeries initiated mine ,collagen 3》6 rather the comp C 1 and thus as you say genetically prone to this phase shift ,then we have seeding ie nutrition on going inflamaftion growth factors snd so forthe ,the reason the surgery is so successfull is that no damage tissue doesn't trigger more myoblasts to release specific growth factors the body is saying my hand is still being damaged to be successfull the collagen must be totally disrupted broken down move back into circulation thus shock wave targeted therapy is intuitively correct then use hherapeutics to help normal healing cycle ,the true treatment gets rid of the diseases tissue and reinstates healthy tissue this way the signalling mrna dna changes .

THOUGHTS PLEASE . High or med more frequent focussed extracirporeal Shock wave therapy this seems ideally suited bothe in disintegration or breaking down collagen and in promoting healing and much less damaging than surgery ,one might combine this with adenilub re Oxfird trial or with collegenaze which should facilitate uptake of drugs ,maybe longer term ultrasound or micro current to encourage full cycle mrna dna signalling regeneration back into the correct liminal pattern and collagen 1 from 3,6 reversion. TH😢OUGHTS PLEASE

They have enzyme treatments now..

I just learned about this and was diagnosed with it. I though it was my Rheumatoid Arthritis and am excited there is a name and maybe help!

I found the beginning interesting, where the chance of having Dupuytren are higher for europeans then for all the other ethnics. But those people also have something else in common: they consume a lot of milk products (butter/cheese/etc..) all calcium rich foods. We also saw in the presentation that magnesium might help slow down the progression, because the cells in the cords are mainly calcium-dependent pathway involved in the activation of MLCK in the nodes. So I'm starting to think that magnesium helps because magnesium and calcium compete for body absorption. So if we take magnesium, we can absorb less calcium, and therfore the MLCK activation slows down. It's also important to consider that magnesium can act as a natural calcium channel blocker, which might influence cellular activities that are calcium-dependent

What an informative, honest and excellent video.

Why is the anti-TNF "early stage" threatment with adalimumab not mentioned? Is it still too unknown?

Can you look at the potential of mesenchymal stem cell injections as possible treatments? Looking at the mechanisms of treatment such as immunomodulation, anti inflammatory, tissue regeneration?